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Genetics and Mental Health: Facts, Myths, and Future Treatments

April 9, 2025by Harrison Levine0

A heritable disease is passed down through genes, increasing the likelihood that a person will develop it if it runs in their family. Mental illnesses like schizophrenia, bipolar disorder, and depression have strong genetic links, but genetics alone do not determine fate. While these conditions have biological roots, environmental factors such as stress, trauma, and lifestyle choices significantly influence their development. Schizophrenia and bipolar disorder have higher heritability, while depression and anxiety are more affected by life experiences. Even with a strong genetic predisposition, these conditions can be managed, prevented, and treated effectively. Therapy, medication, and a stable environment play a crucial role in shaping mental health, proving that genetics set the stage, but they do not write the script.

Gene therapy is already transforming medicine. Somatic gene therapy, which alters body cells, is not heritable and only affects the person receiving it. It is being successfully used to treat diseases like sickle cell disease and cancer1, and because it does not affect future generations, it faces fewer ethical concerns and is widely accepted. Germline gene editing, on the other hand, modifies reproductive cells, making those genetic changes permanent for future generations2. While this could prevent inherited diseases, it raises serious ethical issues, including the potential for unintended consequences and the risk of genetic selection beyond medical needs3. Because of these concerns, germline editing remains banned or heavily restricted worldwide.

 

Gene therapy for mental illness is not yet a reality, but scientific research is advancing rapidly. Unlike single-gene disorders, psychiatric conditions arise from complex interactions between multiple genes and environmental influences, making them more difficult to target4. Researchers are using CRISPR technology to identify and study genetic risk factors5, while also exploring how neurotransmitters like dopamine and glutamate affect disorders such as schizophrenia6. Epigenetics, which examines how environmental factors switch genes on or off, offers another promising avenue7. While there are still major challenges to overcome, the potential for targeted, effective treatments is growing. The future of mental health care will rely on precision medicine, where treatments are tailored to individual genetic and biological profiles, bringing hope for breakthroughs that could transform lives.

Understanding genetics, mental health, and medical advancements is not optional—it is essential. These topics shape the way society approaches medicine, policy, and personal health. A clear understanding of how genetics and environment interact can dismantle stigma, promote early intervention, and lead to more effective treatment8. With rapid progress in gene therapy and neuroscience, young people must be equipped with knowledge to engage in these discussions and make informed decisions. Schools must prioritize teaching these subjects in biology, psychology, and health classes to prepare students for a future where genetic research will play a major role in medicine9. When people are informed, they can challenge misinformation, advocate for better policies, and make educated choices about their own health and the well-being of future generations.

The widespread rejection of science and misinformation about genetics and mental health is a crisis. Many people avoid these topics because they seem complicated or because they were never taught to think critically about them10. Education systems often fail to connect scientific concepts to real life, and social media spreads misinformation faster than facts11. Some reject science because it challenges their beliefs, while others simply do not see how it affects them. This ignorance is not just a personal failing—it has real consequences. When people dismiss medical advancements or fall for conspiracy theories, they put their own health and the health of others at risk. Science is not just for experts; it is for everyone, and it is time to prioritize knowledge over fear.

RFK Jr. has exploited this distrust in science by pushing misinformation about vaccines, medicine, and public health12. He manipulates skepticism toward pharmaceutical companies and government agencies to spread fear and false narratives. His influence thrives in a society where scientific literacy is weak, and misinformation spreads unchecked. People who feel ignored or disillusioned with institutions often turn to alternative explanations, even when they lack evidence. His family name and image as a rebel challenging authority make him appealing to those seeking answers outside mainstream sources, even if those answers are based on fiction rather than facts.

His rise is not just about one person—it is a warning sign of a deeper problem. A society that does not value science and critical thinking is vulnerable to deception, manipulation, and poor decision-making. The only solution is education. If more people were scientifically literate, figures like RFK Jr. would struggle to gain traction. The future depends on people embracing knowledge, rejecting misinformation, and demanding truth over fear. Science is advancing at an incredible pace, and with it comes the power to cure diseases, improve mental health, and extend lives. A world where people understand and trust science is a world where progress is unstoppable. It is not too late to build that future, but it requires a commitment to learning, questioning, and thinking critically. The truth is there for those willing to seek it, and the future will belong to those who choose knowledge over ignorance.

References
  1. Dunbar, C. E., High, K. A., Joung, J. K., Kohn, D. B., Ozawa, K., & Sadelain, M. (2018). Gene therapy comes of age. Science, 359(6372), eaan4672.
  2. National Academies of Sciences, Engineering, and Medicine. (2017). Human Genome Editing: Science, Ethics, and Governance. The National Academies Press.
  3. Lander, E. S., Baylis, F., Zhang, F., Charpentier, E., Berg, P., Doudna, J., & Daley, G. Q. (2019). Adopt a moratorium on heritable genome editing. Nature, 567(7747), 165-168.
  4. Sullivan, P. F., Daly, M. J., & O’Donovan, M. (2018). Genetic architectures of psychiatric disorders: The emerging picture and its implications. Nature Reviews Genetics, 19(8), 537-551.
  5. Schrode, N., Ho, S. M., Yamamuro, K., Dobbyn, A., Huckins, L., Matos, M. R., … & Brennand, K. J. (2019). Synergistic effects of common schizophrenia risk variants. Nature Genetics, 51(10), 1475-1485.
  6. Howes, O. D., & Kapur, S. (2009). The dopamine hypothesis of schizophrenia: Version III—the final common pathway. Schizophrenia Bulletin, 35(3), 549-562.
  7. Nestler, E. J. (2014). Epigenetic mechanisms of depression. JAMA Psychiatry, 71(4), 454-456.
  8. Pescosolido, B. A., Martin, J. K., Long, J. S., Medina, T. R., Phelan, J. C., & Link, B. G. (2010). “A disease like any other”? A decade of change in public reactions to schizophrenia, depression, and alcohol dependence. American Journal of Psychiatry, 167(11), 1321-1330.
  9. Ledford, H. (2019). CRISPR gene-editing in human embryos wreaks chromosomal mayhem. Nature, 574(7776), 464-465.
  10. Lewandowsky, S., Ecker, U. K., Seifert, C. M., Schwarz, N., & Cook, J. (2012). Misinformation and its correction: Continued influence and successful debiasing. Psychological Science in the Public Interest, 13(3), 106-131.
  11. Vosoughi, S., Roy, D., & Aral, S. (2018). The spread of true and false news online. Science, 359(6380), 1146-1151.
  12. Hotez, P. J. (2021). Preventing the Next Pandemic: Vaccine Diplomacy in a Time of Anti-Science. JHU Press.

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